The Rolfe Foundation's mission is to support scientific research that will lead to an early detection test for pancreatic cancer and to fund organizations that specialize in support services for patients and their loved ones. The Foundation is a 501(c)(3) public charity as designated by Internal Revenue Service.

The Foundation was started in 1999 by the family and friends of Michael Rolfe whose untimely death from pancreatic cancer was the inspiration for creating a Foundation to serve as a catalyst for the early diagnosis and ultimate cure of pancreatic cancer.