2017 Grants Awarded

The Rolfe Pancreatic Cancer Foundation was proud to award the following grants in 2016:

Johns Hopkins University

Second and final installment one establishment of Organoid bank for Pancreatic Cancer Precursor Lesions:  Pancreatic cancer arises through non-invasive precursor lesions leading to cancerous tumors.  Identifying these precursor lesions before they become invasive cancer is the key to early detection, treatment and prevention of pancreatic cancer.  In spite of this the majority of research has focused on pancreatic cancer rather than these critical precursor lesions.  One reason for this gap is a lack of model systems in which to study early pancreatic lesions. Pancreatic duct organoids are three-dimensional culture systems that can be used to probe the genetics and biology of pancreatic cancer.  This grant will establish an organoid tissue bank of precursor and normal duct organoid lines from 50 patients.

Circulating Exosomes as biomarker for Pancreatic Cancer:  This grant is for the research of Michael Goggins, M.D.  Exosomes are small extracellular vesicles shed from normal and cancerous cells.  Exosomes can be detected in the circulation as diagnostic biomarkers.  Critical to their potential as diagnostic markers of pancreatic cancer is determining if pancreatic cancer cells are the primary source of these markers.  Dr. Goggins proposes to isolate circulating exosomes to purify potential pancreatic-derived vesicles from other, more abundant extracellular vesicle populations, to confirm pancreatic cancer as the source of these exosomes for superior diagnostic potential.

University of Chicago

Grant to develop U of C’s first familial pancreatic cancer registry.

NYU (Dr. Diane Simeone)

To support development of a familial pancreatic cancer tool that patients can easily put in a comprehensive family history. Will be great asset for clinicians and researchers. Currently the tool is on an iPAD but eventually can be used on any device.

Mayo Clinic

This grant is in support of Dr. Gloria Petersen’s early detection research, “Early Detection for Families of Pancreatic Cancer Patients with Gene Mutations. Dr. Petersen’s project will advance research to generate needed data that will establish recommendations for early detection in family members of pancreatic cancer patients. This project will likely impact pancreatic cancer risk assessment and early detection strategies.

Lustgarten – Intercepting Pancreatic Cancer in High Risk Cohorts

This is Stand Up 2 Cancer/Lustgarten project

Cancer Wellness Center (Northbrook)

For continued support of their pancreatic cancer discussion group.

Wellness House (Hinsdale)

For continued support of their pancreatic cancer discussion group.